The Misdiagnosis of Beta-Thalassemia Heterozygosity Led by Hyperthyroidism
نویسندگان
چکیده
When patients have mild microcytic hypochromic anemia with slightly increased hemoglobin (Hb) A2 fraction, the most likely diagnosis is beta-thalassemia heterozygosity. But herein we found a patient who had all these hematological parameters but did not He was 14-year-old Thai presented fatigue and heat intolerance for 2 weeks. His physical examination revealed diffuse enlargement of thyroid gland. Blood tests showed Hb 120 g/L, mean corpuscular volume (MCV) 72.1 fL, (MCH) 23.3 pg/cell, free triiodothyronine (FT3) > 20 pg/mL, thyroxine (FT4) 5.0 ng/dL, thyrotropin < 2.5 mIU/L, serum ferritin 51.3 µg/L, 3.8%. Besides primary hyperthyroidism, he diagnosed After being treated antithyroid drug 6 months, his blood subclinical 146 MCV 83.3 MCH 26.3 3.0%. Not only hormones levels also concentration, MCV, percentage became normal. Due to this inconsistency, DNA analysis genes performed negative numerous common rare meanwhile beta-globin gene sequencing appeared It should be concluded that hyperthyroidism could induce elevated in normal individual, leading misdiagnosis In other words, during it delayed till achievement euthyroid stage.
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ژورنال
عنوان ژورنال: Ramathibodi Medical Journal
سال: 2022
ISSN: ['2651-0561']
DOI: https://doi.org/10.33165/rmj.2022.45.3.256975